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Table 1 Refined nomenclature for the MV2 subgroups a

From: Deciphering the pathogenesis of sporadic Creutzfeldt-Jakob disease with codon 129 M/V and type 2 abnormal prion protein

  Proposed nomenclature
  Current classificationb PrPSctype Transmission typec Classification Codon 129 genotype PrPSctype Histo-typed Transmission type Original PrPScstrain(s) Existing PrPScstrain(s)
Pure phenotypes MM1 1 M1CJD MM1 MM 1 S M1 M1 M1
MM2C 2 M2CJD MM2C MM 2 C M2C M2C
MV2C 2 N.D.e MV2C MV 2 C N.D. f M2C M2C
MV2K 2 V2CJD MVi + 2 MV i + 2 g K V2 V2 Mi + V2
VV2 2 V2CJD VV2 VV 2 P V2 V2 V2
Mixed phenotype MV2K + C 2 N.D. MVi + 2C MV i + 2 K + C V2 M2C + V2 M2C + Mi + V2
  1. aProposed nomenclature for the classification of sCJD subgroups analyzed in this study.
  2. bAccording to Parchi et al., 1999 [4]; and Parchi et al., 2011 [5].
  3. cAccording to Bishop et al., 2010 [13].
  4. dS, synaptic; C, cortical form; K, kuru plaques; P, plaque-like.
  5. eN.D., not done.
  6. fTransmission experiment is in progress.
  7. gMixture of the intermediate type and type 2 PrPSc.