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Table 1 Refined nomenclature for the MV2 subgroups a

From: Deciphering the pathogenesis of sporadic Creutzfeldt-Jakob disease with codon 129 M/V and type 2 abnormal prion protein

 

Proposed nomenclature

 

Current classificationb

PrPSctype

Transmission typec

Classification

Codon 129 genotype

PrPSctype

Histo-typed

Transmission type

Original PrPScstrain(s)

Existing PrPScstrain(s)

Pure phenotypes

MM1

1

M1CJD

MM1

MM

1

S

M1

M1

M1

MM2C

2

M2CJD

MM2C

MM

2

C

―

M2C

M2C

MV2C

2

N.D.e

MV2C

MV

2

C

N.D. f

M2C

M2C

MV2K

2

V2CJD

MVi + 2

MV

i + 2 g

K

V2

V2

Mi + V2

VV2

2

V2CJD

VV2

VV

2

P

V2

V2

V2

Mixed phenotype

MV2K + C

2

N.D.

MVi + 2C

MV

i + 2

K + C

V2

M2C + V2

M2C + Mi + V2

  1. aProposed nomenclature for the classification of sCJD subgroups analyzed in this study.
  2. bAccording to Parchi et al., 1999 [4]; and Parchi et al., 2011 [5].
  3. cAccording to Bishop et al., 2010 [13].
  4. dS, synaptic; C, cortical form; K, kuru plaques; P, plaque-like.
  5. eN.D., not done.
  6. fTransmission experiment is in progress.
  7. gMixture of the intermediate type and type 2 PrPSc.