Skip to main content
Figure 2 | Acta Neuropathologica Communications

Figure 2

From: Deciphering the pathogenesis of sporadic Creutzfeldt-Jakob disease with codon 129 M/V and type 2 abnormal prion protein

Figure 2

Transmission of sCJD to PrP-humanized mice. The mean incubation times of MV2K-inoculated Ki-Hu129M/M, Ki-Hu129M/V, and Ki-Hu129V/V were 638 ± 57 days (number of mice positive for PrP accumulation in immunohistochemical analysis/number of inoculated mice = 4/4), 713 ± 0 days (3/4), and 329 ± 3 days (4/4), respectively. The mean incubation times of MV2K + C-inoculated Ki-Hu129M/M, Ki-Hu129M/V, and Ki-Hu129V/V were 600 ± 22 days (6/6), 638 ± 11 days (7/7), and 332 ± 15 days (4/4), respectively. The mean incubation times of VV2-inoculated Ki-Hu129M/M, Ki-Hu129M/V, and Ki-Hu129V/V were 633 ± 49 days (6/6), 788 ± 30 days (4/4), and 302 ± 9 days (7/7), respectively. The mean incubation times of MM1-inoculated Ki-Hu129M/M, Ki-Hu129M/V, and Ki-Hu129V/V were 467 ± 24 days (8/8), 490 ± 26 days (5/5), and 774 ± 32 days (6/6), respectively. The details of the transmission experiments of VV2 or MM1 using Ki-Hu129M/M and Ki-Hu129V/V have been reported previously [25, 29].

Back to article page
\