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Table 2 Summary of neuropathological observations

From: Rapidly progressive dementia with thalamic degeneration and peculiar cortical prion protein immunoreactivity, but absence of proteinase K resistant PrP: a new disease entity?

  Case 1 Case 2 Case 3 Case 4 Case 5 Case 6
Region SC G PrP SC G PrP SC G PrP SC G PrP SC G PrP SC G PrP
Frontal Cx + ++ ++ + + + - - + - + + - ++ - + ++ +
Parietal Cx - + - + + ++ - + + - + ++ - ++ ++ + ++ +
Temporal Cx - + + - + - - - - - + + - - - - - -
Occipital Cx - + + - ++ +++ - + +++ - + + - ++ ++ NA NA NA
Entorhinal Cx + - - - - - - - - - - - - - - - - -
Hippocampus - - - - - - - - - - - - - - - - - -
Thalamus-Med - +++ - - +++ - - +++ - - +++ - - +++ - - +++ -
Thalamus-Lat - + - - ++ - - - - - - - - - - - - -
Thalamus-Ant - ++ - - + - - + - - + - - ++ - - ++ -
Caudate nucleus - ++ - - ++ - - + - - ++ - - ++ + - + -
Putamen - + - - ++ - - - - - + - - + - - + -
Globus pallidus - - - - - - - - - - - - - - - - - -
Substantia nigra - + - - - - - - - - + - - + + - + -
Dorsal raphe nucleus - + - - + - - + - - ++ - - + - - - -
Locus coeruleus - - - - - - - - - - - - - - - - - -
Pontine base nuclei - - - - - - - - - - - - - - - - - -
Inferior olive - ++ - - ++ - - + - - ++ - + +++ - ++ ++ -
Dentate nucleus - - - - - - - - - - - - - - - - + -
Cbll Mol layer - - - - - + - - + - - - - - - - - -
Cbll Gran Layer - - - - - - - - - - - - - - - - - -
Purkinje cells - - - - ++ - - - - - - - - - - - - -
  1. SC spongiform change; G gliosis; PrP immunoreactivity for PrP; NA not available; Cx cortex; Med medial; Lat lateral; Ant anterior; Cbll cerebellum. Semiquantitative scoring: – indicates none, +: mild, ++: moderate, +++: severe degree of changes or amount of immunoreactivity.
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Acta Neuropathologica Communications

ISSN: 2051-5960

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