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Figure 4 | Acta Neuropathologica Communications

Figure 4

From: Rapidly progressive dementia with thalamic degeneration and peculiar cortical prion protein immunoreactivity, but absence of proteinase K resistant PrP: a new disease entity?

Figure 4

Western blot analysis of present cases 1, 2, and 4 and an Austrian FFI case using 3F4 as the primary antibody. PrPres type 1, 2A and 2B standards were run in the lanes as indicated. a: PrPres was undetectable in 200 μl (of 10% wt/vol brain homogenate) after centrifugal concentration. b: Centrifugal concentration (100 μl of 10% wt/vol brain homogenate) shows readily detectable PrPres in the A-FFI case. c: PrPres was undetectable in 500 μl of 10% wt/vol brain homogenate from cases 1, 2 and 4 after NaPTA precipitation. FC, frontal cortex; OC, occipital cortex; CB, cerebellum; TC, temporal cortex; H, hippocampus; Thal, thalamus.

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