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Table 2 Neuropathologic findings

From: Cerebellar hemorrhagic injury in premature infants occurs during a vulnerable developmental period and is associated with wider neuropathology

Neuropathological finding CHI Control p value
Periventricular leukomalacia (5/19) 26% (1/26) 4% 0.0687
Germinal matrix hemorrhage (18/19) 95% (14/26) 54% 0.003
Intraventricular hemorrhage Grades 3 or 4 (12/18) 67% (10/14) 71% 1.0
Pontosubicular necrosis (11/16) 69% (7/26) 27% 0.0073
Frontal cortex - neuronal loss (0/19) 0% (0/26) 0% NA
Frontal cortex - gliosis (0/19) 0% (0/26) 0% NA
Parietal cortex - neuronal loss (0/17) 0% (0/24) 0% NA
Parietal cortex - gliosis (0/17) 0% (0/24) 0% NA
Temporal cortex - neuronal loss (0/19) 0% (1/24) 4% 1.0
Temporal cortex - gliosis (0/19) 0% (1/23) 4% 1.0
Occipital cortex - neuronal loss (0/5) 0% (0/2) 0% NA
Occipital cortex - gliosis (0/5) 0% (0/2) 0% NA
Putamen – neuronal loss (1/18) 6% (2/24) 8% 1.0
Putamen – gliosis (1/18) 6% (2/24) 8% 1.0
Caudate – neuronal loss (1/17) 5% (3/26) 12% 1.0
Caudate – gliosis (1/17) 5% (3/26) 12% 1.0
Globus pallidus – neuronal loss (0/14) 0% (0/13) 0% NA
Globus pallidus – gliosis (0/14) 0% (2/13) 15% 0.2222
Thalamus – neuronal loss (2/16) 13% (5/22) 23% 0.6754
Thalamus – gliosis (2/16) 13% (5/22) 23% 0.6754
Hypothalamus- neuronal loss (0/5) 0% (2/3) 66% 0.1071
Hypothalamus – gliosis (0/5) 0% (2/3) 66% 0.1071
Hippocampus – neuronal loss (0/19) 0% (1/22) 5% 1.0
Hippocampus – gliosis (1/19) 5% (1/22) 5% 1.0
Midbrain, tectum – neuronal loss (6/17) 35% (5/24) 21% 0.4757
Midbrain, tectum – gliosis (6/17) 35% (6/24) 25% 0.5072
Midbrain, tegmentum – neuronal loss (0/17) 0% (1/25) 4% 1.0
Midbrain, tegmentum – gliosis (0/17) 0% (2/25) 8% 0.5064
Pons, tegmentum – neuronal loss (2/19) 11% (1/24) 4% 0.5751
Pons, tegmentum – gliosis (5/19) 26% (1/24) 4% 0.0723
Rostral medulla, tegmentum – neuronal loss (3/18) 17% (2/26) 8% 0.3859
Rostral medulla, tegmentum – gliosis (4/19) 21% (7/26) 27% 0.7363
Inferior olivary nucleus – neuronal loss (10/17) 59% (5/26) 19% 0.0077
Inferior olivary nucleus - gliosis (17/18) 94% (18/26) 69% 0.0603
Cerebellar cortex – neuronal loss (15/19) 79% (1/26) 4% <0.0001
Cerebellar cortex – gliosis (15/19) 79% (1/26) 4% <0.0001
Dentate nucleus – neuronal loss (8/15) 53% (0/23) 0% <0.0001
Dentate nucleus - gliosis (9/15) 60% (0/23) 0% <0.0001
Spinal cord – neuronal loss (0/16) 0% (1/23) 4% 1.0
Spinal cord - gliosis (0/16) 0% (1/23) 4% 1.0
  1. Data reported as percentages for categorical variables. NA, statistical testing not applied. Hippocampus refers to all parts of Ammon’s horn, but excludes subiculum. p values in bold denote statistical significance.