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Table 1 Demographic, maternal, and neonatal clinical data

From: Cerebellar hemorrhagic injury in premature infants occurs during a vulnerable developmental period and is associated with wider neuropathology

 

CHI

Control

p value

Demographics

   

Gender: Female

(8/19) 42%

(10/26) 38%

0.8053

Gender: Male

(11/19) 58%

(16/26) 62%

 

Gestational Age (weeks)

24.98 (2.41)

25.88 (2.29)

0.1318

Postnatal Age (weeks)

2.96 (2.71)

2.88 (3.01)

0.6789

Postconceptional Age (weeks)

27.83 (3.50)

28.81 (3.17)

0.3362

Race: African-American

(6/17) 35%

(9/24) 38%

1.0

Race: Caucasian

(10/17) 59%

(14/24) 58%

 

Race: Biracial

(1/17) 6%

(1/24) 4%

 

Birth weight (gm)

746.21 (255.16)

808.54 (228.71)

0.1383

Birth length (cm)

31.91 (3.03)

34.02 (4.07)

0.0376

Birth head circumference (cm)

22.79 (2.57)

23.26 (2.46)

0.5039

Apgar 1 minute

3.53 (2.29)

3.5 (2.34)

0.8701

Apgar 5 minutes

5.12 (2.23)

5.62 (2.40)

0.4593

Postmortem body weight (gm)

1,203.74 (493.93)

1,209.72 (496.38)

0.9683

Postmortem body length (cm)

34.08 (3.04)

35.0 (4.51)

0.4475

Postmortem head circumference (cm)

24.95 (3.31)

25.20 (2.97)

0.7864

Postmortem brain weight, fixed (gm)

115.47 (36.89)

131.77 (41.54)

0.1909

Maternal Factors

   

Maternal Age (years)

24.68 (4.41)

26.12 (7.02)

0.407

Pregnancy induced hypertension

(3/19) 16%

(1/26) 4%

0.2954

Pre-ecclampsia/ecclampsia

(1/19) 5%

(2/24) 8%

1.0

Maternal infection/antibiotics

(9/19) 47%

(12/26) 46%

0.9357

Preterm labor

(16/19) 84%

(26/26) 100%

0.909

Prolonged rupture of membranes

(5/19) 26%

(7/26) 27%

0.9637

Chorioamnionitis

(6/19) 32%

(8/26) 31%

0.9538

Multiple gestation

(4/19) 21%

(7/26) 27%

0.7363

Abruption

(7/19) 37%

(5/26) 19%

0.1870

Prenatal steroids

(15/19) 79%

(18/26) 69%

0.4666

Neonatal Course

   

Cesarean section

(8/19) 42%

(18/26) 69%

0.0688

Emergent delivery

(11/19) 58%

(18/26) 69%

0.4327

Surfactant

(19/19) 100%

(25/26) 96%

1.0

iNO

(6/19) 32%

(7/26) 27%

0.7341

Chest compressions and/or epinephrine

(5/19) 26%

(3/26) 12%

0.2528

Mechanical ventilation

(19/19) 100%

(26/26) 100%

1.0

Positive pressure ventilation (PPV) and intubation

(19/19) 100%

(25/26) 96%

1.0

High frequency oscillatory ventilation (HFOV)

(14/19) 74%

(17/26) 65%

0.5525

Continuous positive airway pressure (CPAP)/nasal cannula

(9/19) 47%

(14/26) 54%

0.6677

Hypoxia

(19/19) 100%

(3/26) 12%

0.2515

Pneumonia

(6/19) 32%

(5/26) 19%

0.4851

Respiratory distress syndrome (RDS)

(19/19) 100%

(25/26) 96%

1.0

Bronchopulmonary dysplasia (BPD)

(5/19) 26%

(8/26) 31%

0.7448

Pneumothorax

(2/19) 11%

(7/26) 27%

0.2644

Pulmonary hemorrhage

(8/19) 41%

(3/26) 12%

0.0333

PDA on ultrasound

(11/17) 65%

(11/21) 53%

0.4442

Indomethacin prophylaxis

(14/19) 74%

(17/26) 65%

0.5525

Ibuprofen/indomethacin

(0/19) 0%

(4/26) 15%

0.1264

Surgical ligation of PDA

(3/19) 16%

(1/26) 4%

0.2954

Vasopressors

(19/19) 100%

(23/26) 88%

0.2515

Hydrocortisone

(13/19) 68%

(13/26) 50%

0.2166

Volume expanders

(19/19) 100%

(24/26) 92%

0.5010

Blood transfusion

(19/19) 100%

(25/26) 96%

1.0

Hyperbilirubinemia

(18/18) 100%

(23/24) 96%

1.0

Disseminated intravascular coagulation

(11/19) 58%

(10/26) 38%

0.1968

Sepsis

(17/19) 89%

(15/26) 58%

0.0152

Meningitis

(0/19) 0%

(0/26) 0%

1.0

Intestinal injury

(10/19) 53%

(12/26) 46%

0.6677

Surgery

(9/19) 47%

(8/26) 31%

0.3532

Feeds

(12/19) 63%

(15/26) 58%

0.7660

Total parental nutrition

(19/19) 100%

(26/26) 100%

1.0

Bicarbonate administered

(19/19) 100%

(25/26) 96%

1.0

Acidosis (pH < 7.20)

(19/19) 100%

(26/26) 100%

1.0

Renal failure

(14/19) 74%

(11/26) 42%

0.0339

Furosamide

(9/19) 47%

(11/26) 42%

0.7358

Pain/sedation medications

(19/19) 100%

(22/26) 85%

0.1264

Seizures

(5/19) 26%

(7/26) 27%

0.9637

  1. Data reported as percentages for categorical variables. For continuous variables data are reported as mean and (standard deviation). p values in bold denote statistical significance.