Table 1 Selected clinical and pathological details of cases investigated by dipeptide immunostaining
Case | M/F | Clinical diagnosis | Pathological diagnosis | Family history | Onset (y) | Duration (y) | Brain weight (g) |
|---|---|---|---|---|---|---|---|
1 | M | FTD | FTLD-TDP type A | 2 brothers, 2 sisters FTD | 49 | 9 | 1050 |
2 | M | FTD | FTLD-TDP type A | brother MND**, mother and grandmother FTD | 60 | 8 | 1210 |
3 | F | FTD | FTLD-TDP type A | none available | 59 | 5 | 1140 |
4 | M | FTD | FTLD-TDP type A | father dementia | 64 | 8 | 1100 |
5 | M | FTD | FTLD-TDP type A | father similar presentation, paternal grandmother 'AD’ | 63 | 2 | na  |
6 | M | FTD | FTLD-TDP type A | yes | 78 | 4 | 1200 |
7 | M | FTD + MND | FTLD-TDP type B | ?paternal aunt said to be 'strange’ | 60 | 2 | na |
8 | M | FTD + MND | FTLD-TDP type B | mother FTD | 57 | 2 | 1210 |
9 | M | FTD | FTLD-TDP type B | mother dementia | 54 | 12 | na |
10 | F | FTD | FTLD-TDP type B | mother and sister FTD | 51 | 19 | na |
11 | F | FTD + MND | FTLD-TDP type B | father 'AD’, sister MND, paternal nephew MND | 63 | 2 | na |
12 | F | FTD + MND | FTLD-TDP type B | sister MND, brother FTD, mother 'multiple sclerosis’ | 68 | 5 | 1363 |
13 | M | FTD | Corticobasal degeneration | father and 5 sisters had Huntington’s disease | 59 | 70 | 1271 |
14 | M | MND | MND | brother FTD**, mother and grandmother FTD | 60 | 5 | 1350 |
15 | F | MND | MND | none available | 40 | 5 | 1330 |
16 | M | MND | MND | brother MND, sister FTD + MND | 53 | 2 | 1250 |
17 | M | FTD | FTLD-tau Pi | none | 69 | 6 | na |
18 | F | FTD | FTLD-tau MAPT +16 | mother: early onset dementia; brother: MND | 48 | 15 | 1100 |
19 | M | Corticobasal Syndrome | FTLD-tau CBD | none | 65 | na | 1020 |
20 | M | FTD | FTLD-TDP A | mother AD, brother AD (but with behavioural problems) | 66 | 7 | 980 |
21 | F | FTD + MND | FTLD-TDP B | none available | 50 | 2 | 1050 |
22 | F | SD | FTLD-TDP C | none | 70 | 2 | 1522 |
23 | F | Alzheimer’s disease | Alzheimer’s disease | none | 74 | 12 | 1220 |
24 | M | Huntington’s disease | Huntington’s disease | none available | 48 | 24 | na |
25 | M | Huntington’s disease | Huntington’s disease | none available | 56 | 19 | 1340 |
26 | M | Normal | Normal control | none | 54* | na | 1720 |
27 | F | Normal | Normal control | none | 53* | na | 1220 |