Figure 4

Proximal sections showing an example of the NFP⁺ , NGFR⁺ and S100⁺ labelling patterns in peripheral nerve fascicle identified in ketamine cystitis tissue and observed in nearly all ketamine cystitis samples. EMA showed a perineural labelling pattern. The prominent perineural spindle cell cuff was also NGFR⁺ and exhibited scanty SMA⁺ restricted to occasional cells. Note, the adjacent blood vessel, which showed SMA labelling of the mural smooth muscle cells, but unlike the nerve fascicle was NFP^-, NGFR^- and S100^-. Scale bar represents 100 μm.