Fetal inflammatory response in CMV-positive inner ears. A) CD8 immunohistochemistry showing numerous CD8-positive lymphocytes in the epithelial layers of the stria vascularis and within the Reissner’s membrane. Lymphocytic infiltrate was mainly found in proximity to cytomegalic cells. B) Granzyme B immunohistochemistry in the stria vascularis: most of the lymphocytes close to CMV infected cells (small arrows) were activated expressing Granzyme B (big arrow). C) CD8 immunohistochemistry showing CD8-positive lymphocytes along the cochlear nerve fibers. D) CD8 immunohistochemistry showing CD8-positive lymphocytes within the spiral ganglion.