Figure 6From: The Arctic AβPP mutation leads to Alzheimer’s disease pathology with highly variable topographic deposition of differentially truncated Aβ Higher magnifications of the Purkinje cell layer from patients Am1 (a) and Sw2 (b) show the abundant Aβ deposition. Granular cytoplasmic staining is observed with abAβ17–24 (most likely AβPP) in a Purkinje cell (a), whereas with abAβx-42 (b) the cytoplasm is negative. Cytoplasmic abAβ17–24 positivity is also seen in Sw2 patient’s cerebellar dentate neurons (c). (bar in a 30 μm; bar in b 50 μm; bar in c 15 μm).Back to article page