Higher magnifications of the Purkinje cell layer from patients Am1 (a) and Sw2 (b) show the abundant Aβ deposition. Granular cytoplasmic staining is observed with abAβ17–24 (most likely AβPP) in a Purkinje cell (a), whereas with abAβx-42
(b) the cytoplasm is negative. Cytoplasmic abAβ17–24 positivity is also seen in Sw2 patient’s cerebellar dentate neurons (c). (bar in a 30 μm; bar in b 50 μm; bar in c 15 μm).