Figure 5

Immunostainings of Sw2 patient’s cerebellum (a, c, d resp. e, f, h, i represent semiconsecutive sections). a-c: C-terminal and mid-domain antibodies abAβ_x-42, abAβ_x-40 and abAβ_17–24 disclose similar pattern. There is abundant deposition in the Purkinje cell layer, from where Aβ deposits extend as streaks towards the surface often loosely following penetrating arteries with distinct CAA. d-i: The more N-terminal (beyond aa 17) abAβ_8–17 (d); abAβ_5–10 (e); and abAβ_1–5 (f), as well as the specific abAβ_arc (g) render markedly weaker staining of the parenchymal deposits, which is also weaker than with the pyroglutamate specific abAβ_3pE (h) and abAβ_11pE (i). With all Aβ antibodies blood vessels stain approximately as strongly. (bar in a 500 μm for all panels).