Immunostainings of Sw2 patient’s cerebellum (a, c, d resp. e, f, h, i represent semiconsecutive sections). a-c: C-terminal and mid-domain antibodies abAβx-42, abAβx-40 and abAβ17–24 disclose similar pattern. There is abundant deposition in the Purkinje cell layer, from where Aβ deposits extend as streaks towards the surface often loosely following penetrating arteries with distinct CAA. d-i: The more N-terminal (beyond aa 17) abAβ8–17
(e); and abAβ1–5
(f), as well as the specific abAβarc
(g) render markedly weaker staining of the parenchymal deposits, which is also weaker than with the pyroglutamate specific abAβ3pE
(h) and abAβ11pE
(i). With all Aβ antibodies blood vessels stain approximately as strongly. (bar in a 500 μm for all panels).