Hippocampal region from patients Sw1 (a-e; consecutive sections) and Sw2 (f). The general pattern of Aβ deposits is fairly similar with all antibodies, although the intensity of staining is somewhat stronger and the size of plaques larger with the C-terminal abAβx-42
(a) and abAβx-40
(b), as well as with the mid-domain abAβ17-24
(c) than with the N-terminal abAβ1-5
(d) and the specific antibodies abAβarc
(e) and abAβ3pE
(f).The insets from the CA4 regions within the squares demonstrate that the plaques are mostly of diffuse type. In addition, especially in sectors CA3 and CA4, there is abundant, diffuse, lightly stained “background” deposition of Aβ. In stratum radiatum (sr) the plaques are somewhat larger and more compact. Note: no targetoid plaques with abAβx-42 and abAβ1-5 (such as in cerebral cortex). (bar in a 1100 μm for all panels).