Figure 4

Hippocampal region from patients Sw1 (a-e; consecutive sections) and Sw2 (f). The general pattern of Aβ deposits is fairly similar with all antibodies, although the intensity of staining is somewhat stronger and the size of plaques larger with the C-terminal abAβ_x-42 (a) and abAβ_x-40 (b), as well as with the mid-domain abAβ_17-24 (c) than with the N-terminal abAβ_1-5 (d) and the specific antibodies abAβ_arc (e) and abAβ_3pE (f).The insets from the CA4 regions within the squares demonstrate that the plaques are mostly of diffuse type. In addition, especially in sectors CA3 and CA4, there is abundant, diffuse, lightly stained “background” deposition of Aβ. In stratum radiatum (sr) the plaques are somewhat larger and more compact. Note: no targetoid plaques with abAβ_x-42 and abAβ_1-5 (such as in cerebral cortex). (bar in a 1100 μm for all panels).