Figure 1From: The Arctic AβPP mutation leads to Alzheimer’s disease pathology with highly variable topographic deposition of differentially truncated Aβ Pedigrees of the Arctic AD families (a and b) and basic pathology in Sw2 patient (c-e). a and b: Pedigrees of the Swedish and American families with the Arctic AβPP gene mutation. Diagonal lines indicate deceased individuals; filled symbols indicate affected and open symbols unaffected members. The patients examined in this study in Family a are: IV:10 = Sw1, IV:29 = Sw2 and in Family b: III:1 = Am1, IV:1 = Am2. c: Sw2 patient’s brain weighed 1490 g. The gyri are only mildly atrophic, whereas the atrophy of hippocampus (arrow) and the dilatation of the ventricular system (asterisks) are obvious. d and e: Semi-consecutive sections from Sw2 patient’s frontal cortex: d: The plaques (five marked with an arrow) are discernible already with H&E staining. They are rounded, compact, eosinophilic structures with homogeneous texture, reminiscent of so called cotton wool plaques [3]. Inset in d: Both pial and penetrating arteries are strongly Congo positive, but no plaques are visible. e: In a Bielschowsky silver impregnated section several plaques are vaguely ring formed (four marked with an arrow). No prominent dystrophic neurites are seen, only short, thin stubs. Inset (the square in e): Occasional plaques harbour somewhat coarser dystrophic neurites (arrow). Open arrow points to a neuron with neurofibrillary tangle. (bar in d 100 μm for d and e; bar in inset of e 40 μm).Back to article page