Neuroinflammation in the striatum. Striatal coronal sections were immunostained for GFAP expression (a). Mean intensity quantification of GFAP (b) and Iba1 (c) staining was conducted in the striatum ipsilateral over contralateral, in the V1S and SV2 or venusYFP group. Data analysis revealed a 9% elevation in the ratio of GFAP expression ipsilateral over contralateral in animals injected with V1S and SV2 (n = 8, p < 0.005) compared to animals injected with full-length venusYFP (n = 4) showing no changes in the level of GFAP expression ipsilateral vs. contralateral (d). Iba1 expression ratio in the V1S SV2 group was similar to the control group (e). Representative images are displayed. Scale bar 500 μm and 20 μm in A, 200 μm in B and C.