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Table 2 List of the demographic data and staining profile of the antibodies in familial AD patients

From: N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody

Gene Mutation Sex Age Plaques (IC16) CAA (IC16) Plaques (NT4X-167) CAA (NT4X-167)
APP Arctic M 64 + + + +
Swedish F 61 + + + +
PS1 PS1 Δ9 M 61 + + + +
M 64 + + + +
   M 69 + + + +
  1. NT4X-167 showed only CAA but almost no plaques in PS1 Δ9 patients, while both CAA and plaques were observable in patients with Arctic and Swedish mutations in the APP gene.
  2. Abbreviations: M male, F female, CAA cerebral amyloid angiopathy.