N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody

Table 1 List of demographic data of sporadic AD patients and non-demented controls and the staining profile of the antibodies

	No	Age Mean±SEM	Sex M/F	Braak stage	ApoE4	Plaques (IC16)	CAA (IC16)	Plaques (NT4X-167)	CAA (NT4X-167)
Sporadic AD	13	76 ± 3	3/10	4-6	7/13	13/13	13/13	3/13	13/13
Controls	10	80 ± 2	6/4	0-1	2/10	5/10	3/10	0/10	3/10

Of note, none of the controls showed NT4X-167 staining of plaques although 5 of them were positive with IC16, demonstrating a clear difference between AD and control cases. The amount of NT4X-167-positive plaques in sporadic AD brain was low.
Abbreviations: No number of cases, M male, F female, ApoE4 number of cases with at least one ApoE4 allele, CAA cerebral amyloid angiopathy.

ISSN: 2051-5960