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Figure 8 | Acta Neuropathologica Communications

Figure 8

From: N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody

Figure 8

NTX4-167 showed no cross-reactivity with diagnostic aggregates in other major neurodegenerative diseases. Lower panels represent parallel sections stained with NT4X-167. (a-c) Alpha-synuclein (α-syn) positive aggregates in Lewy bodies and Lewy neurites in dementia with Lewy bodies and Parkinson disease and glial inclusions in multiple system atrophy. (d) Pathological vessels in Binswanger encephalopathy (subcortical arteriolosclerotic encephalopathy). (e) Phospho-TDP-43 immunoreactive neuronal cytoplasmic inclusions in a patient with frontotemporal lobar degeneration. (f-g) Phospho-tau (pTau) immunoreactive aggregates in progressive supranuclear palsy and in Pick’s disease. (h) Prion protein (PrP) immunopositive synaptic deposits in sporadic Creutzfeldt-Jakob disease. Scale bar in a-f 50 μm, g-h, 200 μm.

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Acta Neuropathologica Communications

ISSN: 2051-5960

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