Figure 7

Immunohistochemical staining of cerebral cortex in patients with familial AD. (a-c) using IC16 antibody and (d-f) parallel sections using NT4X-167 antibody. (a, d) The patient harboring the Arctic mutation elicited positive blood vessels (CAA) and plaques with both antibodies, staining in plaques being less pronounced with NT4X-167. (b, e) The patient with the Swedish mutation also demonstrated positive blood vessels and plaques with both antibodies and again with a weaker staining in plaques with NT4X-167. (c, f) In the patient with the PS1 mutation ∆Exon9, positive blood vessels and plaques were seen with both antibodies again with a less pronounced staining in plaques with NT4X-167. Scale bar: 200 μm.