Figure 4

Cellular toxicity of N-truncated Aβ _x-42 peptides and treatment effect of NT4X-167. In rat primary cortical neurons, all Aβ _x-42 peptides induce significant dose-dependent cellular toxicity. NT4X-167 treatment completely rescues toxic effects of freshly dissolved 1, 5 and 10 μM Aβ_4–42, but not of Aβ_pE3-42 or Aβ_1–42 in vitro (ANOVA, P<0.0001, F= 87.24, dF=17). After ANOVA, the individual groups were subsequently analyzed using Bonferroni multiple comparisons. Abbreviation: ****, P<0.0001.