Cellular toxicity of N-truncated Aβ
peptides and treatment effect of NT4X-167. In rat primary cortical neurons, all Aβ
peptides induce significant dose-dependent cellular toxicity. NT4X-167 treatment completely rescues toxic effects of freshly dissolved 1, 5 and 10 μM Aβ4–42, but not of AβpE3-42 or Aβ1–42
in vitro (ANOVA, P<0.0001, F= 87.24, dF=17). After ANOVA, the individual groups were subsequently analyzed using Bonferroni multiple comparisons. Abbreviation: ****, P<0.0001.