Figure 4

Hepcidin and ferroportin protein expression in control mouse brain. In control mouse brains, hepcidin protein was found in the molecular layer of olfactory bulb (a), in the granule cells of dentate gyrus (b) and white matter tract of striatum (c). Hepcidin and ApoE present in the epithelial cells of choroid plexus (d) and ependymal cells of the ventricular surface of lateral ventricle (e). The immunoreactivity of oligodendrocytes was strong in white matter tracts, particularly in the corpus callosum (CC). Hepcidin (f) and FPN (g) expressed in the white matter tract of CC and both proteins co-localised (h). Scale bar a, b &e 150 μm, c 20 μm, d 50 μm, f-h 25 μm.