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Table 2 Illustrating the diagnostic accuracy of the assessors for particular disease groups when examining the simulated biopsies from the frontal lobe, the temporal lobe and combined

From: Simulated surgical-type cerebral biopsies from post-mortem brains allows accurate neuropathological diagnoses in the majority of neurodegenerative disease groups

Cases No. Correct diagnosis Comments
   C-combined, F-Frontal, T-Temporal  
Control 9 C-9 (100%), F-100%, T-100%  
AD 15 C-15 (100%), F-100%, T-100%  
PSP 3 C-0 (0%), F-0%, T-0% 1 assessor detected*
CBD/MAPT 7 C- 7 (100%), F-100%, T-100%  
DLB 5 C- 3 (60%), F-60%, T-40%  
MSA 3 C- 3 (100%), F-100%, T-100%  
HD 6 C- 5 (83%), F-83%, T-83% 1 assessor missed†
FTLD-TDP/FTLD-MND 6 C- 5 (83%), F-67%, T-83% 1-2 assessor(s) missed #
Metabolic disease 1 C-1 (100%), F-100%, T-100%  
Cerebrovascular disease 1 C-1 (100%), F-100%, T-100%  
ALS 2 C- 0 (0%), F-0%, T-0%  
Combined AD and DLB 4 C-3 (75%), F-75%, T-75% 1 assessor missed in limbic DLB case~
  1. *- 1 assessor diagnosed PSP in one case only.
  2. †- 1 assessor missed diagnosis in one case.
  3. # - 1 assessor missed diagnosis in one case, 1 assessor missed another diagnosis in another case when examining frontal lobe.
  4. ~ - 1 assessor missed diagnosis in one combined AD-DLB case when DLB component was of limbic stage.
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Acta Neuropathologica Communications

ISSN: 2051-5960

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