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Table 2 Illustrating the diagnostic accuracy of the assessors for particular disease groups when examining the simulated biopsies from the frontal lobe, the temporal lobe and combined

From: Simulated surgical-type cerebral biopsies from post-mortem brains allows accurate neuropathological diagnoses in the majority of neurodegenerative disease groups

Cases

No.

Correct diagnosis

Comments

  

C-combined, F-Frontal, T-Temporal

 

Control

9

C-9 (100%), F-100%, T-100%

 

AD

15

C-15 (100%), F-100%, T-100%

 

PSP

3

C-0 (0%), F-0%, T-0%

1 assessor detected*

CBD/MAPT

7

C- 7 (100%), F-100%, T-100%

 

DLB

5

C- 3 (60%), F-60%, T-40%

 

MSA

3

C- 3 (100%), F-100%, T-100%

 

HD

6

C- 5 (83%), F-83%, T-83%

1 assessor missed†

FTLD-TDP/FTLD-MND

6

C- 5 (83%), F-67%, T-83%

1-2 assessor(s) missed #

Metabolic disease

1

C-1 (100%), F-100%, T-100%

 

Cerebrovascular disease

1

C-1 (100%), F-100%, T-100%

 

ALS

2

C- 0 (0%), F-0%, T-0%

 

Combined AD and DLB

4

C-3 (75%), F-75%, T-75%

1 assessor missed in limbic DLB case~

  1. *- 1 assessor diagnosed PSP in one case only.
  2. †- 1 assessor missed diagnosis in one case.
  3. # - 1 assessor missed diagnosis in one case, 1 assessor missed another diagnosis in another case when examining frontal lobe.
  4. ~ - 1 assessor missed diagnosis in one combined AD-DLB case when DLB component was of limbic stage.