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Table 1 Showing the number and range of cases from which simulated brain biopsies were taken

From: Simulated surgical-type cerebral biopsies from post-mortem brains allows accurate neuropathological diagnoses in the majority of neurodegenerative disease groups

Cases Number in group Relevant stages Comments
Control 9 AD (BNE/Braak) 0-II [11]  
AD 15 AD (BNE/Braak) IV-VI 2 cases mild cortical TDP-43
PSP 3   
CBD 5    Total = 7   
MAPT (with CBD pathology) 2
DLB 5 Limbic [10] - 3  
Neocortical - 2
MSA 3   
HD 6   
FTLD-TDP/FTLD-MND 6 FTLD-TDP -1 1 case C9orf72 mutation
FTLD-MND -5  
Metabolic disease 1 Batten’s disease CLN2 mutation
Cerebrovascular disease 1   Infarct and amyloid angiopathy
ALS 2   No extramotor inclusions
Combined AD and DLB 4 AD (BNE Braak) (V-VI) 1 case mild cortical TDP-43
DLB Limbic -2
   DLB Neocortical - 2