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Table 1 Showing the number and range of cases from which simulated brain biopsies were taken

From: Simulated surgical-type cerebral biopsies from post-mortem brains allows accurate neuropathological diagnoses in the majority of neurodegenerative disease groups

Cases

Number in group

Relevant stages

Comments

Control

9

AD (BNE/Braak) 0-II [11]

 

AD

15

AD (BNE/Braak) IV-VI

2 cases mild cortical TDP-43

PSP

3

  

CBD

5    Total = 7

  

MAPT (with CBD pathology)

2

DLB

5

Limbic [10] - 3

 

Neocortical - 2

MSA

3

  

HD

6

  

FTLD-TDP/FTLD-MND

6

FTLD-TDP -1

1 case C9orf72 mutation

FTLD-MND -5

 

Metabolic disease

1

Batten’s disease

CLN2 mutation

Cerebrovascular disease

1

 

Infarct and amyloid angiopathy

ALS

2

 

No extramotor inclusions

Combined AD and DLB

4

AD (BNE Braak) (V-VI)

1 case mild cortical TDP-43

DLB Limbic -2

  

DLB Neocortical - 2