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Table 2 Brain pathology associated with experimental mTBI

From: Blast overpressure induces shear-related injuries in the brain of rats exposed to a mild traumatic brain injury

Animal ID Blast condition Time harvested Lesions observed
B2 1 x 74.5 24 h Tear causing repositioning of part of the caudate-putamen into the insula.
B3 1 x 74.5 24 h Blood in dorsal 3rd and lateral ventricles as well as choroid plexus.
B4 1 x 74.5 24 h Blood in dorsal 3rd and lateral ventricles.
B1 3 x 74.5 24 h Blood in dorsal 3rd ventricle.
B5 3 x 74.5 24 h Blood in aqueduct, dorsal 3rd and lateral ventricles; vascular disruption affecting external capsule and CA1 field; blood in the adjacent parenchymal tissue.
542 3 x 74.5 6 months Tear spanning the perirhinal cortex, external capsule, hippocampal CA1 region and dentate gyrus resulting in tissue architectural abnormalities.
2 3 x 74.5 6 months Lesion in the secondary auditory cortex expanding to the perirhinal region.
1 3 x 74.5 9 months Tear at the surface of the secondary somatosensory cortex extending into the insular cortex; lesion involves repositioning of cortical layers; disruption of piriform cortex by the insertion of olfactory tubercle/lateral olfactory tract tissue.
590 3 x 74.5 10 months Disruption of layers I, II and III in primary visual cortex; presence of ectopic neurons in layer I; lesion of hippocampal CA1.
591 3 x 74.5 10 months Tear and repositioning of layers I, II and III in primary somatosensory cortex; ectopic neurons in layer I; disruption of parietal and somatosensory cortex and ventral/intermediate entorhinal cortex by the insertion of ectopic tissue.
595 3 x 74.5 10 months Lesion in motor cortex altering the cortical architecture.
597 3 x 74.5 10 months Displacement of amygdalohippocampal and posteromedial cortical amygdaloid nucleus tissue disrupting the ventral hippocampal CA1 field.