Blast overpressure induces shear-related injuries in the brain of rats exposed to a mild traumatic brain injury

Sosa, Miguel A Gama; De Gasperi, Rita; Paulino, Alejandro J; Pricop, Paul E; Shaughness, Michael C; Maudlin-Jeronimo, Eric; Hall, Aaron A; Janssen, William G M; Yuk, Frank J; Dorr, Nathan P; Dickstein, Dara L; McCarron, Richard M; Chavko, Mikulas; Hof, Patrick R; Ahlers, Stephen T; Elder, Gregory A

doi:10.1186/2051-5960-1-51

Table 2 Brain pathology associated with experimental mTBI

From: Blast overpressure induces shear-related injuries in the brain of rats exposed to a mild traumatic brain injury

Animal ID	Blast condition	Time harvested	Lesions observed
B2	1 x 74.5	24 h	Tear causing repositioning of part of the caudate-putamen into the insula.
B3	1 x 74.5	24 h	Blood in dorsal 3^rd and lateral ventricles as well as choroid plexus.
B4	1 x 74.5	24 h	Blood in dorsal 3^rd and lateral ventricles.
B1	3 x 74.5	24 h	Blood in dorsal 3^rd ventricle.
B5	3 x 74.5	24 h	Blood in aqueduct, dorsal 3rd and lateral ventricles; vascular disruption affecting external capsule and CA1 field; blood in the adjacent parenchymal tissue.
542	3 x 74.5	6 months	Tear spanning the perirhinal cortex, external capsule, hippocampal CA1 region and dentate gyrus resulting in tissue architectural abnormalities.
2	3 x 74.5	6 months	Lesion in the secondary auditory cortex expanding to the perirhinal region.
1	3 x 74.5	9 months	Tear at the surface of the secondary somatosensory cortex extending into the insular cortex; lesion involves repositioning of cortical layers; disruption of piriform cortex by the insertion of olfactory tubercle/lateral olfactory tract tissue.
590	3 x 74.5	10 months	Disruption of layers I, II and III in primary visual cortex; presence of ectopic neurons in layer I; lesion of hippocampal CA1.
591	3 x 74.5	10 months	Tear and repositioning of layers I, II and III in primary somatosensory cortex; ectopic neurons in layer I; disruption of parietal and somatosensory cortex and ventral/intermediate entorhinal cortex by the insertion of ectopic tissue.
595	3 x 74.5	10 months	Lesion in motor cortex altering the cortical architecture.
597	3 x 74.5	10 months	Displacement of amygdalohippocampal and posteromedial cortical amygdaloid nucleus tissue disrupting the ventral hippocampal CA1 field.

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