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Table 2 Pathological findings in the CNS of NMO and MS patients and controls

From: Intrastriatal injection of interleukin-1 beta triggers the formation of neuromyelitis optica-like lesions in NMO-IgG seropositive rats

Case CNS    Granulocyte Complement IL-1β
number diagnosis CNS area Lesion activity infiltration deposition reactivity
1 NMO spinal cord initial/active +++ yes +++
1 NMO spinal cord initial/active +++ yes +++
2 NMO medulla oblongata initial/active + (1 area) yes +++
3 NMO spinal cord initial/active +++ yes ++
1 NMO spinal cord late/active + yes + (astrocytes)
4 NMO medulla oblongata late/active + low ++
3 NMO optic chiasm late/active +++ low ++
1 NMO pons inactive - no -
1 NMO mesencephalon inactive - no -
1 NMO frontal cortex + WM inactive - no -
1 NMO frontal cortex + WM inactive - no -
5 acute MS occipital cortex initial/active - no -
6 acute MS cerebellum + WM initial/active - no -
7 acute MS cortex + WM initial/active - no -
8 acute MS parietal cortex + WM initial/active + no +
9 acute MS parietal cortex + WM initial/active - no -
10 acute MS medulla oblongata initial/active - no +/− (single cells)
10 acute MS spinal cord initial/active - no +/− (single cells)
11 RRMS spinal cord initial/active - no -
12 PMS spinal cord active - no -
13 PMS optic chiasm late/active - no -
14 PMS spinal cord late/active - no -
15 PMS spinal cord late/active - no +/− (microglia)
16 PPMS insular cortex + WM initial/active - no -
17 SPMS periventricular WM + basal ganglia chronic - no -
18 HSE hippocampus - - no +++
19 No CNS pathology cortex + WM - - no -
20 No CNS pathology temporal cortex + WM - - no -
  1. Semiquantative analysis revealing different extents (−, +, +++) of granulocyte infiltration, complement deposition and IL-1β reactivity in inflammatory lesions of patients with neuromyelitis optica (NMO), acute multiple sclerosis (MS), primary progressive multiple sclerosis (PPMS), secondary progressive MS (SPMS), Herpes simplex encephalitis (HSE) and control cases without any CNS pathology. WM = white matter.