Figure 2

Validated peptide candidates that may block TDP-43 binding determined using a high density peptide array. The peptide mixture inhibits the binding between TDP-43 protein and the membrane. Membranes were incubated with A, TDP-43 protein; B, TDP-43 protein and a mixture of the five candidate peptides; C, TDP-43 protein and the scrambled peptide TC. The data show that the five candidate peptides can effectively inhibit the binding of TDP-43 to the TDP-43 membrane. The experiment was repeated three times with similar results.