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Figure 5 | Acta Neuropathologica Communications

Figure 5

From: Immune complex formation impairs the elimination of solutes from the brain: implications for immunotherapy in Alzheimer’s disease

Figure 5

Quantification of the number of blood vessels labeled with fluorescent dextran following the formation of immune complexes. Control (non-immunized) and OVA-immunized mice where OVA was left intracerebrally for 5 minutes, 24 h, 7 days, followed by the injection of fluorescent dextran and animals sacrificed within 5 mins. (a) The number of capillaries in control and OVA immunized mice, following intracerebral injection of OVA at 5 minutes, 24 h, or 7 days. The number of capillaries labeled with dextran is significantly lower in immunized animals, analyzed 24 h after OVA injection, compared to analysis at 5 minutes. (b) The number of arteries in control and OVA immunized mice, following intracerebral injection of OVA at 5 minutes, 24 h, or 7 days. The number of arteries labeled with dextran is significantly lower in OVA immunized mice where immune complexes were left to form for 24 hours, compared to the control non-immunized group. (c) There is a significant difference between the number of veins with dextran in a perivascular location in the OVA immunized mice analyzed at 24 h or 7 days, compared to control non-immunized mice. *p≤0.001; **p<0.005.

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