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Figure 7 | Acta Neuropathologica Communications

Figure 7

From: Epilepsy: neuroinflammation, neurodegeneration, and APOE genotype

Figure 7

ApoE transcription and translation relative to APOE genotype. Wilcoxon distribution scores for ApoE mRNA levels were higher in patients carrying at least one APOE ϵ4 allele (Group 3 and Group 4) than in those carrying other APOE genotypes (Groups 1 and 2); the difference was significant only between Group 2 and Group 3 (p < 0.01) (A). ApoE protein levels, illustrated in one of eight western blots of different epilepsy samples (n = 92) with actin (red) in the upper row and ApoE (green) in the lower row with the middle sample being recombinant ApoE protein used as a positive control (Std) (B). ApoE protein levels for all the patient samples (n = 92), quantified by western blot analysis, showed that APOE ϵ4,4 patients (Group 4) had lower levels of ApoE than did other APOE genotypes (18.2 ± 8.4 vs 61.8 ± 15.3, 55.4 ± 23.3, 26.9 ± 7.1 arbitrary units) for groups 1, 2, and 3, respectively, p < 0.01 (C).

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