Figure 4

Cross sectional neuronal area in Alzheimer patients and in neurologically normal controls, relative to APOE genotype. Superior temporal gyrus tissue sections from Alzheimer patients (A-C) and neurologically normal patients (D-F) immunoreacted with Pan neuronal marker (green) in Alzheimer patients having APOE ϵ3,3 (A) appeared to be larger than those from Alzheimer patients with APOE ϵ4,4 (B). Cross-sectional area measurements of neurons (μm²) confirm this difference (286 ± 23, vs 227 ± 25; p = 0.009) (C). Cross-sectional area of neurons in control patients with APOE ϵ3,3 (D) was not different from that in control patients with APOE ϵ4,4 (E) (250 ± 16, vs 244 ± 28; p = 0.67) (F).