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Figure 4 | Acta Neuropathologica Communications

Figure 4

From: Evidence of aquaporin involvement in human central pontine myelinolysis

Figure 4

Neuropathology of perilesional areas. Gemistocytes (arrows in a-c) are present and the expression of ( a ) AQP4 (AQP4, scale bar = 50 μm), ( b ) AQP1 (AQP1, scale bar = 50 μm), and ( c ) GFAP (GFAP, scale bar = 50 μm) is increased at the lesions’ borders. ( d ) Vacuolated white matter (HE, scale bar = 250 μm) with the appearance of ( e ) intramyelinic edema (inset shows higher magnification) is a common feature of nonlesional pontine white matter tracts with preserved myelin (PLP, scale bar = 250 μm, inset scale bar = 25 μm), ( f ) normal AQP4 (AQP4, scale bar = 250 μm), ( g ) normal AQP1 (AQP1, scale bar = 250 μm), ( h ) normal GFAP expression (GFAP, scale bar = 250 μm), and ( i ) microglial infiltration (KiM1P, scale bar = 250 μm); ( j ) Normal appearing gray and ( k ) white matter show profound microglial activation with rare clusters of small macrophages (KiM1P, scale bar = 50 μm); Red ischemic neurons ( l ) and ballooned neurons ( m ) are present in the normal appearing gray matter (HE, scale bar = 50 μm).

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