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Figure 3 | Acta Neuropathologica Communications

Figure 3

From: The influence of DNA repair on neurological degeneration, cachexia, skin cancer and internal neoplasms: autopsy report of four xeroderma pigmentosum patients (XP-A, XP-C and XP-D)

Figure 3

Case 3. XP-C A-B: MRI images of brain tumor. A: Axial post contrast T1-weighted MRI image of the brain obtained at age 29y showing a space occupying lesion in the left frontal lobe. The lesion demonstrates decrease signal intensity and does not enhance. The lack of enhancement after contrast indicates low histologic grade of this tumor. B: Axial post contrast T1-weighted MRI image of the brain in the same patient obtained five years later. There is evidence of tumor recurrence after surgery. The tumor demonstrates abnormal increased enhancement on the post contrast scan. This feature is indicative of malignant transformation. C: Histologic features of the primary tumor (as shown in A), a low grade astrocytoma (inset shows slightly atypical cells). D: Histologic features of the recurrent tumor, a glioblastoma. The tumor is characterized by increased cellularity, and pseudo-palisading necrosis (arrow), multinucleated tumor cell is shown in inset. E: Immunohistochemistry shows that the tumor cells are positive for IDH1 (X200). F: Pigmented lesion showing irregular size, shape and color. G: Histology of F showing melanoma in situ (x400).

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