Erbin was decreased and p42/p44 MAPK activity enhanced in diabetic sciatic nerve. Sciatic nerves were isolated from 9, 12 (A) and 16-week (C) control and diabetic mice (n = 8–9 per group). Protein lysates were prepared and Erbin levels and p42/p44 MAPK (pErk) levels were determined by immunoblot. Quantification demonstrated a significant decrease of Erbin levels (B) and an increase in p42/p44 MAPK activation at 16 weeks (D). (*, p < 0.05 versus Veh; **, p < 0.01 versus Veh).