Figure 9
From: Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
Co-localization of p62 with αS inclusions in 8 month-old M20 Tg mice following neonatal brain injection of exogenous αS. Double-labeled immunofluorescence analysis in the midbrain region for p62 (red) and pSer129 (green) showing that most pSer129+ hyperphosphorylated αS inclusions are p62+ in a symptomatic 15 month-old M83 Tg mouse (A) and 8 month-old M20 Tg mice neonatally injected in the brain with 25 μg 21–140 fibrillar (fib) αS (B) or 25 μg Δ71-82 (C). Cell nuclei were counter stained with DAPI. Scale bar = 100 μm.