Figure 8
From: Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
Detection of αS inclusions in M20 Tg mice 8 months after PO brain injection of exogenous αS with both amino-terminal αS antibody SNL-4 and pSer129. Double-labeled immunofluorescence of midbrain with SNL-4 (red) and pSer129 (green) shows that pSer129+ hyperphosphorylated αS inclusions are SNL-4+ in a symptomatic 15 month-old M83 Tg mouse (A) and 8 month-old M20 Tg mice neonatally injected in the brain with 25 μg 21–140 fibrillar (fib) αS (B) or 25 μg Δ71-82 (C). Cell nuclei were counter stained with DAPI. Scale bar = 100 μm.