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Figure 7 | Acta Neuropathologica Communications

Figure 7

From: Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein

Figure 7

IHC showing similar αS pathology induced by neonatal brain injection of fibrillar human 21–140 αS and Δ71-82 human αS in M20 Tg mice compared to a symptomatic M83 Tg mouse. Brainstem tissue sections from a 15 month-old symptomatic M83 Tg mouse (A) and 8 month-old M20 Tg mice neonatally injected in the brain with 25 μg 21–140 fibrillar (fib) αS (B) or 25 μg Δ71-82 (C) show similar staining of αS inclusions as detected with pSer129 by IHC. αS inclusions are also detected with Syn506 and p62 antibodies. Syn506 is a mouse monoclonal antibody that conformationally detects αS inclusions; and p62 is a rabbit polyclonal antibody, which non-specifically recognizes intracellular protein aggregates. Scale bar = 100 μm.

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