Figure 4

Schematic representation of the distribution of αS pathology at 8 months following brain neonatal injection of 21–140 human αS fibrils or Δ71-82 human in M20 αS Tg mice. M20 Tg mice injected with 25 μg of fibrillar (fib) 21–140 human αS (A) or Δ71-82 human αS (B). Maps show rostral-caudal distribution of αS inclusions via coronal sections. Equivalent density and distribution of αS pathology was seen bilaterally. Pathology was detected with antibodies pSer129 and Syn506. (A) P0 injection of 21–140 human αS fibrils results in the formation of αS inclusions throughout the cortex, hippocampus, midbrain, brainstem, and spinal cord. (B) P0 injection of Δ71-82 human αS also results in widespread αS inclusions. The distribution of inclusions was very similar in all mice with pathology.