Figure 2

Schematic summary showing predominant cortical distribution of αS pathology in nTg mice 8 months after brain neonatal injection of fibrillar 21–140 αS. nTg mice injected with 25 μg 21–140 fibrillar (fib) αS. Map shows rostral-caudal distribution of αS inclusions via coronal sections. Equivalent density and distribution of αS pathology was seen bilaterally. Pathology was detected with antibodies pSer129 and Syn506. As shown in representative images, small, rounded perinuclear αS inclusion and neuritic profiles were found sparsely distributed in the cortex. The distribution of inclusions was very similar in all mice with pathology. Scale bar = 50 μm.