Figure 10

Induction of αS pathology throughout the neuroaxis 8 months after neonatal brain injection of 25 μg Δ71-82 αS in M20 Tg mice. Tissue sections were stained with pSer129. Round perikaryal inclusions and dystrophic neurites were diffusely spread throughout the brain and spinal cord. The more rounded, Lewy body-like pathology was seen predominantly in the medial preoptic area (MPA), striatum (ST), thalamus (TH), hypothalamus (HYP), substantia nigra (SN), and ventral pons (VP). Lewy neurite-like pathology extending into the cellular processes was more predominantly seen in the entorhinal cortex (EC), amygdala (AMY), and CA3 region of the hippocampus (CA3). Tissue sections were counterstained with hematoxylin. Scale bars = 100 μm (MPA), 50 μm (EC), 100 μm (ST), 100 μm (AMY), 200 μm (CA3), 50 μm (TH), 100 μm (HYP), 50 μm (SN), and 100 μm (VP).