Figure 4

TMEM106B expression is more disorganized in neurons from GRN (+) FTLD-TDP cases, despite comparable levels of TDP-43 pathology. Representative frontal cortical sections from a normal control (a), GRN (−) FTLD-TDP (b), and GRN (+) FTLD-TDP (c). Both the N2077 antibody (top row) [24] and a different polyclonal antibody (middle row) raised against the N-terminus (amino acids 1–96) of TMEM106B [23] show similar patterns of immunoreactivity on serial sections from the same cases. GRN (+) FTLD-TDP cases showed more disorganized TMEM106B expression than GRN (−) FTLD-TDP cases, despite similar degrees of TDP-43 pathology, as indicated by staining against pathological, phosphorylated forms of TDP-43 (bottom row). Scale bar represents 50 um.