Figure 6

Integrated summary of metagene expression, associated clinical features, and GSEA. The schematic relationship between mouse and human tumours in terms of network genes is shown in the top panel. Expression heatmaps showing the network metagene and CIS genes in 108 MBs by subgroup [38, 39], together with the incidence of metastatic disease, are shown in the middle panel. For all genes, data from the most highly expressed Affymetrix probe are shown. In the metastases track, red = presence, green = absence, grey = no data. In the histological subtype track, magenta = classic, green = desmoplasia, blue = LCA. A schematic of key processes relevant to tumour biology identified by GSEA is shown in the bottom panel. For details of GSEA, see text and Additional file 9: Table S6.