A neuronally enriched transcription factor network is defined by MB
CIS genes. MB CIS genes (enlarged) linked via nearest neighbours
are shown. The topological arrangement of connected CIS nodes is highly
significant (p<0.006) as the average minimum path distance between
the 7 CISs is lower than in 994/1000 randomly resampled networks. All
network edges are supported with a bootstrapped p-value of
<1x10-8. Genes identified as biallelically mutated MB
CISs by Wu et al.  are shown as diamonds. Genes with transcription regulator
activity (GO ID 30528) are shown in yellow. Genes with enriched
ontologies associated with differentiated neurons (GO IDs 45202, 44456,
45211, 43005, 43198) are shown in green. Other genes with a known role
in neuronal development are shown with a green border. For details of
network construction, see Additional file 7.
For details of enriched ontologies see Additional file 6: Table S4.