The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer’s disease

Table 4 Subject information

	n	Avg age of onset	Avg age at death	Avg disease duration	% female	Avg PMI
Normal – age-matched	15	N/A	71.7(8.4)	N/A	46.7	12.7(8.5)
Normal – non age-matched	12	N/A	54.5(24.9)	N/A	66.7	9.1(3.4)
Normal - total	27	N/A	64.0(19.4)	N/A	56.7	11.1(6.9)
PSP	17	66.8(5.8)	73.7(5.2)	6. 7(2.2)	64.7	11.7(6.0)
AD	9	65.0(6.3)	75.8(5.1)	10. 8(3.4)	44.4	9.4(5.8)

There were no significant differences between groups for average age at death (ANOVA, p = 0.33), post-mortem interval (ANOVA, p = 0.54), average age of onset (PSP and AD only, Student’s t-test, p = .45) or percent female (Chi Square, p = 0.89). Average disease duration for AD was significantly longer than for PSP (Student’s t-test, p = 0.002). Standard deviations indicated inside parenthesis.

ISSN: 2051-5960