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Table 1 P-values for comparison of pPERK and pEIF2α immunoreactivity in PSP, AD, and normal controls for different brain regions

From: The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer’s disease

Comparison groups   Pons   Medulla   Midbrain   Hippocampus   Frontal cortex   Cerebellum
pPERK peIF2α pPERK peIF2α pPERK peIF2α pPERK peIF2α pPERK peIF2α pPERK peIF2α
AD vs. Normal 3.4E-5 0.0045 0.034 0.041 0.0026 0.0037 0.0006 0.0042 4.1E-5 4.1E-5 0.4 1
PSP vs. AD 3.8E-4 0.00049 1.7E-4 0.028 4.0E-7 0.009 0.000021 8.2E-5 1.6E-4 0.0049 0.5 1
PSP vs. Normal 3.8E-9 4.1E-5 6.1E-7 6.0E-6 6.0E-6 1.4E-4 0.0034 0.073 0.0045 0.1 1 1
  1. P-values are from a Fisher exact test. “E” indicates “x 10^”. pPERK and peIF2α staining in PSP brainstem areas (pons, medulla, midbrain) were significantly greater than in AD or normal brainstem areas. AD brainstem areas had significantly more pPERK and peIF2α staining than normal brainstem areas. In contrast, primary AD-affected brain areas (hippocampus, frontal cortex) had significantly more pPERK and peIF2α staining than PSP or normal hippocampus and frontal cortex. There was no difference in staining between AD, PSP, or normal brains in the cerebellum.