Figure 5

Hyperphosphorylated tau and pPERK partially co-localize in PSP pons and AD hippocampus. a. Example of a neuron co-stained for htau (red) and pPERK (green). Tau staining is widespread and diffuse. pPERK staining is punctate and localized to the soma and proximal neurites. b. pPERK staining occurred mostly in cells with diffuse, non-fibrillar htau staining. Cells with dense, fibrillar htau staining did not stain for activated PERK (*). c. In PSP pons, most pPERK positive cells also stained for htau (72%), whereas fewer than half of htau stained cells (43%) also stained positive for pPERK. d. htau and pPERK staining overlapped very little in AD hippocampus (14% and 20%). Scale bars are 50 μm unless otherwise indicated.