Figure 8

Rapamycin-regulated genes differentially expressed in both mild and advanced AD. Heat map of the 65 rapamycin-regulated genes that were shown to be differentially expressed in both mild and advanced AD compared to control, in separate two-class unpaired SAM analyses. The cut-off point for differential expression was <10% FDR. The heat map was generated with Cluster and Treeview, with complete hierarchical clustering by gene and array. The expression level of each gene relative to the median expression of the gene across all samples is represented on a red-green colour scale. The colours represent the log ratio of gene expression in an individual patient. Downregulated genes are represented in green (saturated green: log ratios −3.0 and below) while upregulated genes are represented in red (saturated red: log ratios 3.0 and above). Cells with log ratios of 0 (gene expression unchanged) are black. The arrays are identified by the patient codes that are described in Additional file 2: Table S1 (C: Control, L: Limbic stage AD, N: Neocortical stage AD) while the genes are identified by the gene name.