Data are from 3 mice per group; mice were analyzed between 250–280 days post-infection with RML scrapie as described in the Methods. Area counted: Uninfected =10.88 mm2, scrapie-infected = 19.52 mm2. Results similar to those in Tables 5 and 6 were also observed in uninfected C57BL/10 mice (data not shown). Data for arteries and veins for uninfected versus scrapie-infected Tg44+/+ mice were not significantly different by two-tailed Fischer’s exact test (p = 0.64). In contrast, there was a highly significant difference in numbers of arteries and veins associated with FITC-OVA (Table 6) versus PrPres (Table 2) in scrapie-infected mice (P < 0.0001) by two-tailed Fischer’s exact test.