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Table 5 Immunofluorescence analysis of FITC-ovalbumin association with capillaries, arteries and veins in uninfected and scrapie-infected Tg44+/+ mice at 30 min after microinjection of tracer

From: Unusual cerebral vascular prion protein amyloid distribution in scrapie-infected transgenic mice expressing anchorless prion protein

  Uninfected Scrapie-infected
Vessels N % N %
Capillaries 1297 96 935 97
Arteries & Veins 50 4 29 3
Total 1347 100 964 100
  1. Data are from 3 mice per group; mice were analyzed between 250–280 days post-infection with RML scrapie as described in the Methods. Area counted: Uninfected = 5.63 mm2. Scrapie-infected = 9.01 mm2. There was a highly significant difference in numbers of capillaries versus arteries plus veins associated with FITC-OVA (Table 5) versus PrPres (Table 1) in scrapie-infected mice (P < 0.0001) by two-tailed Fischer’s exact test.
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