Inhibiting KDM1A using small molecules, tranylcypromine or NCL-1, effectively suppressed medulloblastoma cell growth in vitro . a The DAOY and ONS-76 medulloblastoma cell lines were treated with the indicated concentrations of the monoaminoxidase inhibitor, tranylcypromine, and cell viability was measured by the MTT assay. Extinction relative to solvent-treated cultures at 72 h is shown for the mean of 4 experiments conducted in triplicate. b The medulloblastoma cell lines, DAOY and ONS-76 were treated 72 h with 10 μM of the KDM1A-selective inhibitor, NCL-1, or with solvent, then cell viability was measured in MTT assays. Bars represent the means of 3 independent experiments conducted in triplicate. ***p < 0.0001.