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Table 1 D-2HG and αKG levels in individual spots in sections of othotopic xenografts carrying the IDH1-R132H mutation (italic) or wild-type IDH

From: Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG

Spot number

D-2-HG (μg/g)

α-KG (μg/g)

1

0.0

0

2

4.7

11.2

3

2.9

5.2

4

6.5

17.2

5

4.7

5.2

6

8.3

11.2

7

4.7

17.2

8

66.7

52.9

9

311

35

10

819.8

0

11

653.9

17.2

53

650.2

17.2

54

194.3

5.2

14

0

0

15

0

5.2

18

358.4

17.2

17

254.5

17.2

16

312.9

5.2

19

4.7

23.1

20

6.5

5.2

21

37.5

41

22

63

82.7

23

39.3

41

24

4.7

5.2

25

4.7

17.2

26

6.5

17.2

27

15.6

11.2

28

46.6

35

29

17.4

17.2

30

88.6

52.9

  1. Spots 1-6 represent normal brain.