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Table 1 Synergistic effects of fluvastatin and celecoxib combination in U87-MG and U118 cell lines

From: Evidence for new targets and synergistic effect of metronomic celecoxib/fluvastatin combination in pilocytic astrocytoma

  U118 U87-MG
Fluvastatin (μM) 240 480 240 480
Celecoxib (μM)
50 >1 0, 444 0,498 0,417
80 >1 0,339 0,458 0,296
100 0,345 0,375 0,009 0,368
130 0,889 0,824 0,057 0,491
260 0,445 +/-1 0,115 +/-1
  1. Growth inhibition assays were performed on U87-MG and U118 cell lines using the MTT assay after 48 h incubation with a range of concentrations of fluvastatin and celecoxib. The combination index (CI) of fluvastatin and celecoxib was calculated using the median effect method (Chou and Talalay method). CI values less than 1 indicate synergy, CI equal to 1 indicates an additive affect, and CI greater than 1 indicates antagonism between the two drug agents.