TY - JOUR AU - Banzhaf-Strathmann, Julia AU - Claus, Rainer AU - Mücke, Oliver AU - Rentzsch, Kristin AU - van der Zee, Julie AU - Engelborghs, Sebastiaan AU - De Deyn, Peter P. AU - Cruts, Marc AU - van Broeckhoven, Christine AU - Plass, Christoph AU - Edbauer, Dieter PY - 2013 DA - 2013/05/13 TI - Promoter DNA methylation regulates progranulin expression and is altered in FTLD JO - Acta Neuropathologica Communications SP - 16 VL - 1 IS - 1 AB - Frontotemporal lobar degeneration (FTLD) is a heterogeneous group of neurodegenerative diseases associated with personality changes and progressive dementia. Loss-of-function mutations in the growth factor progranulin (GRN) cause autosomal dominant FTLD, but so far the pathomechanism of sporadic FTLD is unclear. SN - 2051-5960 UR - https://doi.org/10.1186/2051-5960-1-16 DO - 10.1186/2051-5960-1-16 ID - Banzhaf-Strathmann2013 ER -